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Although microfracture (MFX) recruits mesenchymal stem cells (MSCs) to defects and promotes fibrocartilage repair, its efficacy wanes over time (Paka et al., 2025)

This generates only a comfortable warmth similar to a warm palmfar below the threshold that could cause skin burns

Upon entering a hypoxic environment, T cells rapidly activate their intracellular oxygen-sensing mechanisms (169)

Furthermore, an increased risk of cholestasis has been demonstrated in women with a lower melatonin concentration (27) and the effectiveness of melatonin administration in lowering blood pressure and extending the duration of pregnancy in the course of pre-eclampsia has been confirmed (28)